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Tesofensine vs Semaglutide

If you’re exploring medical weight loss options, you’ve likely heard about tesofensine and semaglutide.

Both have helped people lose significant weight, but they work in different ways.

Choosing the right one depends on your body, your goals, and how you want to approach your weight loss journey.

In this guide, we’ll break down tesofensine vs semaglutide in plain language.

You’ll learn how they work, what kind of results to expect, possible side effects, and how we can help at Eternity Health Partners with both options.

 

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Tesofensine vs Semaglutide at a Glance

 

Feature Tesofensine Semaglutide
Drug Type SNDRI (affects brain chemicals) GLP-1 agonist (affects appetite hormones)
How It Works Reduces appetite and boosts energy Slows digestion and curbs appetite
Form Daily pill Weekly injection
Average Weight Loss 10–12% in 6 months 10–15% in 6–12 months
Common Side Effects Dry mouth, insomnia, increased heart rate Nausea, constipation, fatigue
Good Fit For Fast results, pill preference Gradual, steady weight loss

 

What to Know About Tesofensine

 

Tesofensine helps with weight loss by increasing levels of three key brain chemicals: dopamine, serotonin, and norepinephrine.

These chemicals work together to reduce hunger, improve mood, and increase energy.

People often feel less hungry within the first few days, which makes it easier to stick with a healthy eating plan.

 

Weight loss results

 

Studies show that people using tesofensine can lose around 10 to 12 percent of their body weight in about six months.

Results can be even better when paired with changes in eating and activity.

 

Side effects to consider

 

Tesofensine can sometimes cause side effects like dry mouth, restlessness, or trouble sleeping.

These symptoms are usually mild and may go away as your body adjusts.

 

Who it might be right for

 

Tesofensine could be a great option if:

  • You’ve had side effects with GLP-1 medications
  • You’re looking for quicker appetite control
  • You prefer a once-a-day pill over an injection

 

What to Know About Semaglutide

 

Semaglutide mimics a natural hormone in your body called GLP-1.

This hormone helps you feel full longer by slowing how quickly your stomach empties.

It also helps balance blood sugar levels.

 

Weight loss results

 

Studies show that with semaglutide, you can expect to lose about 10 to 15 percent of your body weight over six to twelve months.

Weight loss tends to happen gradually, which is ideal for people who want a steady, long-term approach.

 

Side effects to consider

 

Common side effects include nausea, bloating, and constipation, especially at the beginning.

Most people find these symptoms improve after a few weeks.

 

Who it might be right for

 

Semaglutide might be a better choice if:

  • You’re managing type 2 diabetes or insulin resistance
  • You’re looking for a long-term weight management solution
  • You’re comfortable with a weekly injection

 

How Tesofensine and Semaglutide Compare

 

Let’s break down tesofensine vs semaglutide:

 

Speed of results

 

Tesofensine often works faster.

Some people see appetite changes within a few days.

Semaglutide works more gradually, with most weight loss happening over several months.

 

Tolerability

 

Tesofensine may cause more sleep or mood-related side effects.

Semaglutide’s side effects are usually tied to digestion.

 

Convenience

 

Tesofensine is a daily pill.

Semaglutide is a weekly injection.

Your comfort with each format can help you decide which is better for your lifestyle.

 

Which one is right for you?

 

It really comes down to your personal goals and how your body responds:

  • Prefer pills? Tesofensine is a great option.
  • Managing blood sugar? Semaglutide may work better.
  • Want quick results? Tesofensine could be a faster start.
  • Prefer slow and steady? Semaglutide fits that path.

 

SEE WHICH OPTION IS RIGHT FOR YOU

 

We Can Help You Find The Right Fit Between Tesofensine vs Semaglutide

 

At Eternity Health Partners, we specialize in helping people lose weight safely and sustainably.

Whether you’re interested in tesofensine, semaglutide, or just want to understand your options, we’ll guide you through it.

Our programs are tailored to you—your body, your goals, your timeline.

We combine science-backed medications with support that keeps you motivated and moving forward.

Ready to get started?

Reach out today and let’s talk about what’s right for you.

 

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FAQs: Tesofensine vs Semaglutide

 

What are the benefits of retatrutide vs semaglutide?
Retatrutide is a newer weight loss medication that targets multiple hormone receptors—GLP-1, GIP, and glucagon—compared to semaglutide, which only targets GLP-1. This multi-pathway action may lead to greater fat loss and appetite suppression. Some early studies suggest retatrutide may offer faster and more significant weight loss than semaglutide.

What are the benefits of tirzepatide vs semaglutide?
Tirzepatide activates both GLP-1 and GIP receptors, which can lead to better blood sugar control and increased weight loss compared to semaglutide. People using tirzepatide in clinical trials have seen slightly higher weight loss percentages than those using semaglutide, especially when combined with lifestyle changes.

What is the best injection for weight loss?
The best injection for weight loss depends on your health goals and how your body responds. Semaglutide and tirzepatide are both highly effective and widely used. Retatrutide is an emerging option that may offer even more weight loss, but it’s not as widely available yet. We help you choose the right one based on your personal profile and preferences.

What is cagrilintide semaglutide?
Cagrilintide and semaglutide are sometimes studied together for enhanced weight loss effects. Cagrilintide mimics the hormone amylin, which works alongside GLP-1 medications like semaglutide to control appetite and slow stomach emptying. This combination is still being researched, but early results are promising for people with obesity.

What are the side effects of tesofensine?
Tesofensine may cause dry mouth, insomnia, restlessness, or increased heart rate. Some people experience mild anxiety or trouble sleeping, especially when starting out. These effects usually fade over time or can be managed by adjusting the dose.

What are the side effects of semaglutide?
Semaglutide commonly causes nausea, constipation, bloating, or fatigue, especially during the first few weeks. Most people adjust to the medication over time. In rare cases, it may lead to more serious effects like gallbladder issues, which is why medical supervision is important.

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DR. EVE HARMONY, ND

Prior to joining the team at Eternity Health Partners, Dr. Harmony worked alongside an MD in a busy General Practice clinic that specialized in primary care for all patients, as well as Hormone Replacement Therapy, IV therapy, regenerative joint injections, peptide injections, ozone treatments, hyperbaric oxygen therapy, and weight management. As a skilled diagnostician, Dr. Harmony has helped hundreds of patients to optimize their health with both Western medicine treatments and natural therapies.

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MEET ELIZABETH BECKNER AND DAISHA ESCAMILLA

OUR CALIFORNIA LICENSED PHLEBOTOMISTS

Liz started doing personal blood draws after her son, Dashiell, was born with Zellwegers disease. His diagnosis required numerous blood draws and drug levels throughout his life. After sitting through long wait times at the labs followed by watching many different phlebotomists, many new to the job, struggle to find his veins, often poking him multiple times, as a seasoned phlebotomist, Liz decided to draw his blood at home and hand deliver it to the lab myself. Soon after she began doing personal touch blood draws so she can now offer that same personalized service to you.

Liz graduated from Pepperdine University with a degree in Biology in 1994. She moved to Santa Barbara and earned her phlebotomy certificate in 1995. Liz began working at St. Francis Medical Center in the Physical Therapy Department and quickly transferred to the Laboratory. Perfecting her venipuncture techniques on all floors of the hospital, including post-operative patients, pregnant women going into labor, sick or premature babies, and emergency room patrons, she then improved her patient care skills working for internal medicine doctors, one of whom was the Medical Director of Hospice and won Doctor of the Year. In 1999, Liz started working with a group of local retinal surgeons. Her primary job consisted of injecting dye into arm veins and photographing its flow through the patients retinal vessels. When patients are worried about their diagnosis or apprehensive about the procedure because of difficult veins, her quick, almost pain free needle stick and kind but professional bed side manner would put them at ease.

The various settings and patients Liz has encountered over the years have enabled her to become very skilled at finding the smallest and most fragile of vessels. Her specialities include infants and the elderly, diabetics of all ages, patients with rolling veins, on blood thinners or chemotherapy. She lives in downtown Santa Barbara, travels from Goleta to Carpintera and brings all the necessary supplies directly to you. All she needs from you is a lab request and your home or office becomes an instant draw station. Appointment times are very flexible, and she is friendly, reliable and punctual. Be kind to your arm and treat yourself to the luxury blood draw you deserve!!!

MEET MICHAEL BROOKINS; BS, CNMT, ABAAHP

Mike brings more than just a medical perspective to his clients; at the age of 14, he began an athletic career as a pole-vaulter that would end up taking him on an incredible journey over the next 13 years of his life. Throughout his athletic journey Mike was constantly working to find the ideal balance of fitness and proper nutrition in order to maximize his performances. Combined with his medical knowledge the years of athletic experience provide a unique and successful combination that serve to benefit his staff and clients.

“After I shifted the focus of my practice from Sports Medicine into Nuclear Medicine specifically Interventional Endocrinology. I found myself questioning our western medical paradigm…Here I was performing thyroid cancer and Hyperthyroidism treatments with harmful radical thyroid radioactive ablations which really made me take a hard look in the mirror and become more of a researcher to find safer and more effective options to better treat my clients. During my research I realized that there were very few, if any, medically directed programs focused towards achieving a “Healthier Lifestyle” rather than typical “Diet” fads.” A few years later after training and working with some of the worlds foremost Bio-identical Hormone Replacement specialists I became Board Certified in Anti-Aging and Regenerative Medicine. Sort of just found my passion and the answers I had been looking for with this new specialty finally after years of treating people with the Band-Aid “fix it when its broken” mentality instead of at the root cause.”

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